Barsottini O G P, Ferraz H B, Seviliano M M, Barbieri A
Setor de Distúrbios do Movimento, Departamento de Neurologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
Braz J Med Biol Res. 2002 Apr;35(4):431-6. doi: 10.1590/s0100-879x2002000400004.
The objective of the present study was to determine whether brain single-photon emission computed tomography (SPECT) imaging is capable of detecting perfusional abnormalities. Ten Sydenham's chorea (SC) patients, eight females and two males, 8 to 25 years of age (mean 13.4), with a clinical diagnosis of SC were submitted to brain SPECT imaging. We used HMPAO labeled with technetium-99m at a dose of 740 MBq. Six examinations revealed hyperperfusion of the basal ganglia, while the remaining four were normal. The six patients with abnormal results were females and their data were not correlated with severity of symptoms. Patients with abnormal brain SPECT had a more recent onset of symptoms (mean of 49 days) compared to those with normal SPECT (mean of 85 days) but this difference did not reach statistical significance. Brain SPECT can be a helpful method to determine abnormalities of the basal ganglia in SC patients but further studies on a larger number of patients are needed in order to detect the phase of the disease during which the examination is more sensitive.
本研究的目的是确定脑单光子发射计算机断层扫描（SPECT）成像是否能够检测灌注异常。10例患有Sydenham舞蹈病（SC）的患者，8名女性和2名男性，年龄在8至25岁之间（平均13.4岁），临床诊断为SC，接受了脑SPECT成像检查。我们使用了剂量为740MBq的锝-99m标记的六甲基丙烯胺肟（HMPAO）。6项检查显示基底神经节灌注增加，其余4项检查结果正常。6例结果异常的患者均为女性，其数据与症状严重程度无关。与SPECT结果正常的患者（平均85天）相比，脑SPECT结果异常的患者症状出现时间更近（平均49天），但这种差异未达到统计学意义。脑SPECT可以作为确定SC患者基底神经节异常的一种有用方法，但需要对更多患者进行进一步研究，以便检测出该检查更敏感的疾病阶段。
