子痫前期中因子V、凝血酶原和亚甲基四氢叶酸还原酶基因变异的频率
Frequency of factor V, prothrombin and methylenetetrahydrofolate reductase gene variants in preeclampsia.
作者信息
D'Elia Angela V, Driul Lorenza, Giacomello Roberta, Colaone Roberta, Fabbro Dora, Di Leonardo Cristina, Florio Pasquale, Petraglia Felice, Marchesoni Diego, Damante Giuseppe
机构信息
Department of Biomedical Science and Technology, University of Udine, Udine, Italy.
出版信息
Gynecol Obstet Invest. 2002;53(2):84-7. doi: 10.1159/000052998.
BACKGROUND
The association between thrombophilic variants (Leiden mutation of the factor V gene, G20210A mutation of the prothrombin gene and C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene) with preeclampsia was investigated in a north-eastern Italian population.
METHODS
Fifty-eight preeclamptic (PE) women and 74 normal pregnancies were evaluated. Genotypes were determined by polymerase chain reaction.
RESULTS
The frequency of heterozygous carriers of the factor V Leiden was similar between PE women (5.2%) compared to the control subjects (4.1%; p 0.76). Also the frequencies of G20210A and C677T mutations were similar between PE and control subjects.
CONCLUSIONS
In this population, we found no difference in the prevalence of genetic risk factors for thrombosis in women with preeclampsia compared with control subjects.
背景
在意大利东北部人群中，研究了血栓形成倾向变异（凝血因子V基因的莱顿突变、凝血酶原基因的G20210A突变和亚甲基四氢叶酸还原酶（MTHFR）基因的C677T多态性）与子痫前期之间的关联。
方法
对58例子痫前期（PE）妇女和74例正常妊娠者进行评估。通过聚合酶链反应确定基因型。
结果
与对照组（4.1%；p = 0.76）相比，PE妇女中凝血因子V莱顿杂合子携带者的频率相似（5.2%）。PE组和对照组中G20210A和C677T突变的频率也相似。
结论
在该人群中，我们发现子痫前期妇女与对照组相比，血栓形成遗传危险因素的患病率没有差异。
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