Ojinnaka N C, Iloeje S O
Department of Paediatrics, University of Nigeria Teaching Hospital, Enugu, Nigeria.
Cent Afr J Med. 2001 Jan;47(1):18-9. doi: 10.4314/cajm.v47i1.8586.
A wide range of adverse effects has been reported following prolonged use of anticonvulsant drugs. More commonly reported adverse effects for ethosuximide include gastric disturbances, psychiatric disorders and Systemic Lupus Erythematosus (SLE). Rare instances of leukopenia and pancytopenia have been noted. A case is presented of a 12 year old girl who developed generalized lymphadenopathy with progressive weight loss and leukopenia following prolonged use of ethosuximide for simple absence seizures. The enlarged lymph nodes regressed with withdrawal of the drug but re-appeared when the drug was recommenced. Sodium valproate was then introduced and ethosuximide discontinued. The seizures were successfully controlled with sodium valproate. Histopathology report of the lymphnode biopsy showed marked reactive lymphnode hyperplasia.
长期使用抗惊厥药物后已报告有多种不良反应。乙琥胺更常报告的不良反应包括胃肠道不适、精神障碍和系统性红斑狼疮（SLE）。已注意到罕见的白细胞减少和全血细胞减少病例。本文介绍了一名12岁女孩的病例，该女孩因长期使用乙琥胺治疗单纯失神发作而出现全身淋巴结肿大、体重逐渐减轻和白细胞减少。肿大的淋巴结在停药后消退，但重新用药时又再次出现。随后引入丙戊酸钠并停用乙琥胺。癫痫发作通过丙戊酸钠成功得到控制。淋巴结活检的组织病理学报告显示有明显的反应性淋巴结增生。
