Svartberg Johan, Carlsen Sven M, Cappelen Johan, Aanderud Sylvi, Johansen Morten Lund, Schreiner Thomas, Kollevold Tormod, Bakke Søren, Bollerslev Jens
Endokrinologisk seksjon Medisinsk avdeling Universitetssykehuset i Nord-Norge 9038 Tromsø.
Tidsskr Nor Laegeforen. 2002 Feb 20;122(5):494-8.
Prolactinoma represents the most commonly occurring hormone-secreting pituitary adenoma. The majority of prolactinomas are small, only rarely do we find larger prolactinomas, so-called macroadenomas. They are almost exclusively benign. The symptoms are mainly caused by elevated prolactin levels and result in changes to the reproductive and sexual function. In cases of macroprolactinomas, symptoms caused by local mass effects can be seen. A variety of other conditions may also cause hyperprolactinaemia; the goal of the examination is to identify the cause.
We have reviewed recent literature and compared findings with current management of hyperprolactinaemia and prolactinoma in Norwegian university hospitals.
The primary treatment is medical, intended to normalize prolactin levels, restore gonadal function, and reduce tumour size. With the new selective dopamine agonists, the treatment is often simple and efficient, but not all patients are in need of treatment.
泌乳素瘤是最常见的分泌激素的垂体腺瘤。大多数泌乳素瘤体积较小，很少能发现较大的泌乳素瘤，即所谓的大腺瘤。它们几乎都是良性的。症状主要由泌乳素水平升高引起，导致生殖和性功能改变。在大泌乳素瘤病例中，可出现局部占位效应引起的症状。多种其他情况也可能导致高泌乳素血症；检查的目的是确定病因。
我们回顾了近期文献，并将研究结果与挪威大学医院目前对高泌乳素血症和泌乳素瘤的治疗方法进行了比较。
主要治疗方法是药物治疗，旨在使泌乳素水平正常化，恢复性腺功能，并缩小肿瘤大小。使用新型选择性多巴胺激动剂，治疗通常简单有效，但并非所有患者都需要治疗。
