Øksengård Anne Rita, Engedal Knut
Nasjonalt kompetansesenter for aldersdemens Geratrisk avdeling Ullevål universitetssykehus 0407 Oslo.
Tidsskr Nor Laegeforen. 2002 Feb 20;122(5):530-1.
To supply relevant information about the genetics of Alzheimer's disease.
Data from the literature (Medline) and personal experiences.
Two well-known risks for developing Alzheimer's disease are established: advanced age and genetic factors. Mutations linked to autosomal dominant familial Alzheimer's disease are known in chromosomes 21, 14 and 1. A non-mendelian Alzheimer's disease with complex aetiology is linked to the apolipoprotein E in chromosome 19.
Children of patients with Alzheimer's disease have a three to four fold increased risk of developing the disease compared to a person without a parent with Alzheimer's disease. The diagnostic benefit of apolipoprotein E genotyping is still uncertain.
提供有关阿尔茨海默病遗传学的相关信息。
来自文献（医学在线数据库）的数据及个人经验。
确定了两个患阿尔茨海默病的已知风险因素：高龄和遗传因素。与常染色体显性家族性阿尔茨海默病相关的突变存在于21号、14号和1号染色体中。一种病因复杂的非孟德尔式阿尔茨海默病与19号染色体上的载脂蛋白E有关。
与没有患阿尔茨海默病父母的人相比，阿尔茨海默病患者的子女患该病的风险增加三到四倍。载脂蛋白E基因分型的诊断价值仍不确定。
