[一氧化氮供体SIN-1对大鼠心肌肌浆网钙转运的影响]
[Effects of nitric oxide donor SIN-1 on calcium transport in rat cardiac sarcoplasmic reticulum].
作者信息
Harmatina O Iu, Azarov V I, Moĭbenko O O
机构信息
A. A. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
出版信息
Fiziol Zh (1994). 2001;47(6):10-4.
The effects of non-enzymatic disintegration of SIN-1 products (nitric oxide, superoxide anion and peroxynitrite) on Ca(2+)-transport of sarcoplasmic reticulum were studied on homogenates of rats myocardium. It was shown that SIN-1 (30 microM) exerts a significant activating effect on ryanodine-sensitive calcium channels resulted in three-fold increase of Ca2+ release rate via these channels. Such effect of SIN-1 realized mainly by nitric oxide effect and, partially, superoxide radical. SIN-1 did not effect the Ca(2+)-ATPase activity of sarcoplasmic reticulum.
在大鼠心肌匀浆上研究了SIN-1产物（一氧化氮、超氧阴离子和过氧亚硝酸盐）的非酶促分解对肌浆网钙转运的影响。结果表明，SIN-1（30微摩尔）对兰尼碱敏感的钙通道有显著的激活作用，导致通过这些通道的钙离子释放速率增加了三倍。SIN-1的这种作用主要通过一氧化氮实现，部分通过超氧自由基实现。SIN-1对肌浆网的Ca(2+)-ATP酶活性没有影响。
Zotero 插件