Usenko A B, Emel'ianova T G, Miasoedov N F
Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 117977 Russia.
Izv Akad Nauk Ser Biol. 2002 Mar-Apr(2):192-204.
Based on the authors' and published data, the spectrum of biological activities of dermorphins was theoretically analyzed for the first time from the viewpoint of specific structural features of their molecule that determine selective affinity to mu-opiate receptors. It was shown that specific distribution of dermorphins and corresponding opiate receptors in tissues and organs, especially in the CNS structures, determines the role of dermorphins in the regulation of functions of the most important physiological systems.
基于作者自身及已发表的数据，首次从决定对μ阿片受体具有选择性亲和力的分子特定结构特征的角度，对皮啡肽的生物活性谱进行了理论分析。结果表明，皮啡肽和相应阿片受体在组织和器官中，尤其是在中枢神经系统结构中的特定分布，决定了皮啡肽在调节最重要生理系统功能中的作用。
