Benn Christine Stabell, Balde Aliu, George Elisha, Kidd Michael, Whittle Hilton, Lisse Ida Marie, Aaby Peter
Lancet. 2002 Apr 13;359(9314):1313-4. doi: 10.1016/S0140-6736(02)08274-0.
We have previously reported that vitamin A supplementation with measles vaccine at age 9 months increases measles-specific antibody concentrations in children at age 18 months compared with placebo. We examined these children when they reached age 6-8 years. Fewer vitamin A-supplemented children had non-protective antibody concentrations (p=0.0095); among children with protective antibody levels, vitamin A-supplemented children tended to have higher geometric mean antibody titres (p=0.09). Thus, simultaneous administration of vitamin A and measles vaccine at age 9 months had a long-term effect on measles-specific antibody levels and may contribute to improved measles control in less-developed countries.
我们之前曾报道，与安慰剂相比，9月龄时补充维生素A与麻疹疫苗同时接种可提高18月龄儿童的麻疹特异性抗体浓度。我们在这些儿童6至8岁时对他们进行了检查。补充维生素A的儿童中抗体浓度无保护作用的较少（p=0.0095）；在抗体水平有保护作用的儿童中，补充维生素A的儿童几何平均抗体滴度往往更高（p=0.09）。因此，9月龄时同时接种维生素A和麻疹疫苗对麻疹特异性抗体水平有长期影响，可能有助于在欠发达国家改善麻疹防控。
