Yamamoto Yasuyuki
Department of Laboratory Medicine, Tokyo Medical University.
Nihon Rinsho. 2002 Apr;60(4):769-74.
Recently, resistance testing of HIV-1 become available to clinicians in Japan. Retrospective studies show that results of these tests predict the response to salvage therapy, and randomized, controlled clinical trials show short-term virologic benefits of resistance testing as a guide to selecting salvage regimens. But the ultimate role for resistance testing in HIV clinical practice is yet to be determined fully. Both phenotypic and genotypic tests have yet to be fully standardized. Interpretation of results is still an 'art', and access to testing is still limited by cost considerations. This review will describe some of the tools that are available for interpreting genotypic assays.
最近，日本的临床医生可以获得HIV-1耐药性检测。回顾性研究表明，这些检测结果可预测挽救治疗的反应，随机对照临床试验表明，耐药性检测作为选择挽救方案的指南具有短期病毒学益处。但耐药性检测在HIV临床实践中的最终作用尚未完全确定。表型和基因型检测都尚未完全标准化。结果的解读仍然是一门“艺术”，而且检测的可及性仍然受到成本因素的限制。本综述将介绍一些可用于解读基因型检测的工具。
