[早期发育和致癌过程中染色质组织的变化]

[Changes in chromatin organization during early development and carcinogenesis].

作者信息

Hair A, Razin S V, Vasetskiĭ E S

机构信息

Gene Expression Group, School of Biological Sciences, University of Manchester, Stopford Building, Oxford Rd, Manchester M13 9PT.

出版信息

Ontogenez. 2002 Mar-Apr;33(2):85-9.

PMID:11969077

Abstract

Similar changes in chromatin organization take place during development and carcinogenesis. The size of chromatin loop domains fixed on the nuclear skeleton (matrix) increased from 20 to approximately 200 kbp. These changes are accompanied by an increased size of replicons and altered specificity of loop attachment to the nuclear matrix. During carcinogenesis, inverse changes in the chromatin structure are observed, neoplastic cells are dedifferentiated and return to the initial state. In this review, we consider new experimental data on organization of the DFNA loops and nuclear matrix in embryogenesis and carcinogenesis.

摘要

在发育和致癌过程中会发生染色质组织的类似变化。固定在核骨架（核基质）上的染色质环域大小从20千碱基对增加到约200千碱基对。这些变化伴随着复制子大小的增加以及环与核基质附着特异性的改变。在致癌过程中，观察到染色质结构的反向变化，肿瘤细胞去分化并回到初始状态。在本综述中，我们考虑了关于胚胎发生和致癌过程中DFNA环和核基质组织的新实验数据。