染色质重塑与DNA复制：从核小体到环状结构域

Chromatin remodelling and DNA replication: from nucleosomes to loop domains.

作者信息

Demeret C, Vassetzky Y, Méchali M

机构信息

Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France.

出版信息

Oncogene. 2001 May 28;20(24):3086-93. doi: 10.1038/sj.onc.1204333.

DOI:10.1038/sj.onc.1204333

PMID:11420724

Abstract

Organization of DNA into chromatin is likely to participate in the control of the timing and selection of DNA replication origins. Reorganization of the chromatin is carried out by chromatin remodelling machines, which may affect the choice of replication origins and efficiency of replication. Replication itself causes a profound rearrangement in the chromatin structure, from nucleosomes to DNA loop domains, allowing to retain or switch an epigenetic state. The present review considers the effects of chromatin remodelling on replication and vice versa.

摘要

DNA组装成染色质可能参与DNA复制起点的时间控制和选择。染色质重塑机器负责染色质的重塑，这可能会影响复制起点的选择和复制效率。复制本身会导致染色质结构发生深刻重排，从核小体到DNA环结构域，从而保留或转换表观遗传状态。本综述探讨了染色质重塑对复制的影响，反之亦然。