Cigaina Valerio
Unit of Digestive Surgical Electrophysiology, Umberto I Hospital, Mestre-Venezia, Italy.
Obes Surg. 2002 Apr;12 Suppl 1:12S-16S. doi: 10.1007/BF03342141.
A novel method to treat morbid obesity is presented--gastric electrical pacing. Following animal research, human investigation in a total of 24 patients in three cohorts began in 1995.
Morbidly obese subjects (BMI > or = 40) received electrical stimulation devices in 1995/6 (n = 4), 1998 (n = 10) and 2000 (n = 10). Electrodes were positioned intramuscularly on the anterior gastric wall at the lesser curvature. BMI = body mass index; %EBL = % excess BMI (> 25) lost.
Patients reported satiety for food with less food. The 2 patients from the first study followed for > 5 years have achieved 38 and 67 %EBL. In the second study, every patient lost weight. At 36 months follow-up, the mean %EBL was 24 +/- 10 SD (n = 10).
Implantable gastric pacing is a safe procedure and causes changes in eating habits in morbidly obese humans, resulting in decreased food intake and weight loss.
介绍了一种治疗病态肥胖的新方法——胃电刺激。在动物研究之后，1995年开始了对总共24名患者分三个队列进行的人体研究。
1995/1996年（n = 4）、1998年（n = 10）和2000年（n = 10），病态肥胖受试者（BMI≥40）接受了电刺激装置。电极经肌肉注射置于胃小弯前壁。BMI = 体重指数；%EBL = 超重BMI（>25）减轻的百分比。
患者报告摄入较少食物时就有饱腹感。第一项研究中随访超过5年的2名患者超重BMI分别减轻了38%和67%。在第二项研究中，每名患者都减轻了体重。在36个月的随访中，平均超重BMI减轻百分比为24±10标准差（n = 10）。
可植入式胃起搏是一种安全的手术，可使病态肥胖人群饮食习惯发生改变，从而减少食物摄入量并减轻体重。
