患有和未患有血栓形成倾向的女性中早发型子痫前期和宫内生长受限的胎盘病理学

Placental pathology in early onset pre-eclampsia and intra-uterine growth restriction in women with and without thrombophilia.

作者信息

Sikkema J M, Franx A, Bruinse H W, van der Wijk N G, de Valk H W, Nikkels P G J

机构信息

Department of Obstetrics, University Medical Center, Utrecht, The Netherlands.

出版信息

Placenta. 2002 Apr;23(4):337-42. doi: 10.1053/plac.2001.0785.

DOI:10.1053/plac.2001.0785

PMID:11969345

Abstract

OBJECTIVE

The incidence of placental thrombotic lesions in early onset preeclampsia (PE) and/or intrauterine growth restriction (IUGR) were compared between women with and without thrombophilia or hyperhomocysteinemia.

STUDY DESIGN

Matched case-control study. 183 women with a history of early onset PE and/or IUGR were tested for thrombophilia and hyperhomocysteinemia. From the 66 women with a thrombophilic factor the placental histological slides were available in 47 women. These were matched for maternal condition (PE and/or IUGR), gestational age at delivery, parity and maternal age, to 47 women with no thrombophilic factor. All slides were revised for lymphohistiocytic villitis, fetal thrombosis and fibrin depositions.

RESULTS

There were no significant differences between the placentas of the matched groups with and without a thrombophilic factor.

CONCLUSION

Placental thrombotic and inflammatory lesions associated with early onset PE and/or IUGR do not occur more often in women with compared to women without thrombophilia or hyperhomocysteinemia.

摘要

目的

比较有或无血栓形成倾向或高同型半胱氨酸血症的女性中，早发型子痫前期（PE）和/或胎儿生长受限（IUGR）患者胎盘血栓性病变的发生率。

研究设计

配对病例对照研究。对183例有早发型PE和/或IUGR病史的女性进行血栓形成倾向和高同型半胱氨酸血症检测。在66例有血栓形成倾向因素的女性中，47例有胎盘组织学切片。将这47例与47例无血栓形成倾向因素的女性进行配对，配对因素包括产妇情况（PE和/或IUGR）、分娩时孕周、产次和产妇年龄。所有切片均检查是否存在淋巴细胞性绒毛炎、胎儿血栓形成和纤维蛋白沉积。