Karkkainen Marika J, Alitalo Kari
Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute, Biomedicum Helsinki, Helsinki University Hospital and University of Helsinki, 00014 Helsinki, Finland.
Semin Cell Dev Biol. 2002 Feb;13(1):9-18. doi: 10.1006/scdb.2001.0286.
Vascular endothelial growth factor receptor-3 (VEGFR-3) mediates lymphatic endothelial cell (LEC) growth, migration, and survival by binding VEGF-C and VEGF-D. Recent studies have revealed new regulators of the lymphatic endothelium, such as the transcription factor Prox1, and the cell surface proteins podoplanin and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1). Furthermore, the isolation of LECs now allows detailed molecular studies of the factors regulating the lymphatic vasculature. These studies are aimed at targeting the lymphatic vasculature in the treatment of various diseases, such as tumour metastasis and lymphoedema.
血管内皮生长因子受体-3（VEGFR-3）通过结合VEGF-C和VEGF-D来介导淋巴管内皮细胞（LEC）的生长、迁移和存活。最近的研究揭示了淋巴管内皮的新调节因子，如转录因子Prox1、细胞表面蛋白血小板反应蛋白1和淋巴管内皮透明质酸受体-1（LYVE-1）。此外，现在对淋巴管内皮细胞的分离使得对调节淋巴管系统的因子进行详细的分子研究成为可能。这些研究旨在针对淋巴管系统来治疗各种疾病，如肿瘤转移和淋巴水肿。
