健康成年人的垂体-甲状腺轴、甲状腺体积与瘦素

Pituitary-thyroid axis, thyroid volume and leptin in healthy adults.

作者信息

Gómez J M, Maravall F J, Gómez N, Gumà A, Casamitjana R, Soler J

机构信息

Endocrinology and Radiology Services, Ciudad Sanitaria y Universitaria de Bellvitge, L'Hospitalet de Llobregat, Hormonal Laboratory, Hospital Clínic, Barcelona, Spain.

出版信息

Horm Metab Res. 2002 Feb;34(2):67-71. doi: 10.1055/s-2002-20529.

DOI:10.1055/s-2002-20529

PMID:11972289

Abstract

OBJECTIVE

Patients with thyroid diseases usually have disturbances relating to body weight and thermogenesis. On the other hand, leptin is involved in the regulation of body weight, food intake and thermogenesis. Some studies have investigated the relationship between leptin and dysthyroid states, but the complex interactions between leptin and pituitary-thyroid axis have led to controversial results.

DESIGN

The aims of this cross-sectional study were to investigate the relationship among basal TSH, ultrasonographic thyroid volume and leptin in a group of 268 healthy adults randomly selected from our city, L'Hospitalet de Llobregat, Barcelona, an area free of iodine deficiency. In this euthyroid group, we determined basal TSH, thyroid autoantibodies, leptin concentrations, and thyroid volume by ultrasonography, body anthropometry, and body composition.

RESULTS

All subjects were free of goitre and were negative for anti-thyroid antibodies. Basal TSH concentrations were 1.49 +/- 0.8 mU/l in males and 1.67 +/- 0.83 mU/l in females (p = 0.6). Anti-thyroid antibodies were negative in all cases; leptin concentrations were 6.1 +/- 4 ng/ml in males and 16.8 +/- 11.7 ng/ml in females (p = 0.0001). Thyroid volume was 9.8 +/- 4.6 ml in males and 6.5 +/- 2 ml in females (p = 0.001). There were significant correlations among leptin concentrations and anthropometric and body composition variables in both sexes, without correlation with TSH concentrations. There was no significant correlation between anthropometric and body composition variables and thyroid volume in males but there was a correlation in females. In females, there was a positive correlation between leptin and thyroid volume (r = 0.181, p = 0.038). In males, there was a negative correlation between TSH concentrations and thyroid volume (r = - 0.271, p = 0.002).

CONCLUSIONS

We did not find any correlation between leptin levels and pituitary-thyroid axis in this control population. The correlation between leptin and thyroid volume in females is probably a consequence that leptin and thyroid volume are regulated in parallel by variables relating to anthropometry and body composition.

摘要

目的

甲状腺疾病患者通常存在与体重和产热相关的紊乱。另一方面，瘦素参与体重、食物摄入和产热的调节。一些研究调查了瘦素与甲状腺功能异常状态之间的关系，但瘦素与垂体 - 甲状腺轴之间复杂的相互作用导致了有争议的结果。

设计

这项横断面研究的目的是在从我们城市（巴塞罗那的略夫雷加特医院，一个无碘缺乏地区）随机选取的268名健康成年人中，研究基础促甲状腺激素（TSH）、甲状腺超声体积与瘦素之间的关系。在这个甲状腺功能正常的组中，我们通过超声检查、人体测量和身体成分分析来测定基础TSH、甲状腺自身抗体、瘦素浓度和甲状腺体积。

结果

所有受试者均无甲状腺肿，抗甲状腺抗体均为阴性。男性基础TSH浓度为1.49±0.8 mU/l，女性为1.67±0.83 mU/l（p = 0.6）。所有病例抗甲状腺抗体均为阴性；男性瘦素浓度为6.1±4 ng/ml，女性为16.8±11.7 ng/ml（p = 0.0001）。男性甲状腺体积为9.8±4.6 ml，女性为6.5±2 ml（p = 0.001）。两性中瘦素浓度与人体测量和身体成分变量之间存在显著相关性，与TSH浓度无关。男性中人体测量和身体成分变量与甲状腺体积之间无显著相关性，但女性中有相关性。在女性中，瘦素与甲状腺体积呈正相关（r = 0.181，p = 0.038）。在男性中，TSH浓度与甲状腺体积呈负相关（r = - 0.271，p = 0.002）。