用于评估大鼠肾实质和肾盂中氮氧自由基动力学的体内时间分辨电子顺磁共振成像

In vivo temporal EPR imaging for estimating the kinetics of a nitroxide radical in the renal parenchyma and pelvis in rats.

作者信息

Ueda Atsushi, Yokoyama Hidekatsu, Nagase Sohji, Hirayama Aki, Koyama Akio, Ohya Hiroaki, Kamada Hitoshi

机构信息

Institute for Life Support Technology, Yamagata Public Corporation for the Development of Industry, Yamagata, Japan.

出版信息

Magn Reson Imaging. 2002 Jan;20(1):77-82. doi: 10.1016/s0730-725x(02)00467-8.

DOI:10.1016/s0730-725x(02)00467-8

PMID:11973032

Abstract

The kinetics of a nitroxide radical in the renal parenchyma and pelvis in rats were investigated by employing an in vivo EPR imaging system equipped with a surface-coil-type resonator (SCR). The exposed kidney of a living rat was inserted into the single-turn coil of the SCR, with the renal major axis aligned with the direction of alternative magnetic field (B(1)). After the injection of nitroxide radical via the tail vein, EPR measurements were repeated. From the temporal EPR images of the kidney on the 2-D projection to the plane which is perpendicular to the direction of B(1,) the decay rate of nitroxide radical in the renal parenchyma and pelvis was estimated. The parenchymal decay rate was found to be significantly shorter than that for the pelvis.

摘要

通过使用配备表面线圈型谐振器（SCR）的体内电子顺磁共振成像系统，研究了大鼠肾实质和肾盂中氮氧化物自由基的动力学。将一只活大鼠暴露的肾脏插入SCR的单匝线圈中，使肾脏的长轴与交变磁场（B(1)）的方向对齐。经尾静脉注射氮氧化物自由基后，重复进行电子顺磁共振测量。从肾脏在垂直于B(1)方向的平面上的二维投影的时间电子顺磁共振图像中，估计了肾实质和肾盂中氮氧化物自由基的衰减率。发现实质衰减率明显短于肾盂的衰减率。