通过低频电子顺磁共振研究全小鼠体内一氧化氮自由基的药代动力学。
Whole mouse nitroxide free radical pharmacokinetics by low frequency electron paramagnetic resonance.
作者信息
Ferrari M, Colacicchi S, Gualtieri G, Santini M T, Sotgiu A
机构信息
Dipartimento di Scienze e Tecnologie Biomediche e Biometria, Università dell'Aquila, Italy.
出版信息
Biochem Biophys Res Commun. 1990 Jan 15;166(1):168-73. doi: 10.1016/0006-291x(90)91926-j.
The in vivo uptake distribution and reduction of the oxygen-sensitive nitroxide spin label PCA in the mouse monitored by low frequency electron paramagnetic resonance (EPR) spectroscopy are reported. Spectra were obtained from the head and liver regions of pentobarbital anesthetized mice during different circulatory and ventilatory conditions. Identical clearances were found in these regions during normoxia. Moderate hypoxia (10% O2-90% N2) did not significantly affect the spin label reduction rate.
报道了通过低频电子顺磁共振（EPR）光谱监测的氧敏感型氮氧自由基自旋标记物PCA在小鼠体内的摄取分布及还原情况。在不同的循环和通气条件下，从戊巴比妥麻醉小鼠的头部和肝脏区域获取光谱。在常氧条件下，这些区域的清除率相同。中度缺氧（10% O₂ - 90% N₂）对自旋标记物的还原速率没有显著影响。
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