患有移植物抗宿主病的异基因骨髓移植受者的白内障手术(1)。
Cataract surgery in allogeneic bone marrow transplant recipients with graft-versus-host disease(1).
作者信息
Penn Esther A, Soong H Kaz
机构信息
W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA.
出版信息
J Cataract Refract Surg. 2002 Mar;28(3):417-20. doi: 10.1016/s0886-3350(01)01165-8.
PURPOSE
To study the outcomes of cataract surgery in allogeneic bone marrow transplant recipients with documented graft-versus-host disease (GVHD) and to elucidate the concomitant ocular surface problems often encountered in these patients.
SETTING
W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA.
METHODS
This retrospective study comprised 12 cataract surgeries in 7 patients with GVHD) after allogeneic bone marrow transplantation. In particular, visual acuity improvement, surgical complications, and problems associated with concomitant ocular surface disease were reviewed.
RESULTS
The mean visual acuity improved significantly from 20/46 (logMAR 0.32) preoperatively to 20/21 (logMAR 0.02) postoperatively (P <.005). The mean postoperative follow-up was 23 months (range 3 to 48 months). All patients had dry eyes, and 3 had conjunctival cicatrization with mild keratinization. No patient had postoperative corneal breakdown.
CONCLUSION
With aggressive management of dry eyes and other ocular surface problems, cataract surgery had excellent outcomes in patients with GVHD.
目的
研究有记录的移植物抗宿主病（GVHD）的异基因骨髓移植受者白内障手术的结果，并阐明这些患者常伴随出现的眼表问题。
背景
美国密歇根大学安娜堡分校W.K.凯洛格眼科中心。
方法
这项回顾性研究纳入了7例异基因骨髓移植后发生GVHD的患者的12次白内障手术。特别回顾了视力改善情况、手术并发症以及与伴随的眼表疾病相关的问题。
结果
平均视力从术前的20/46（logMAR 0.32）显著提高到术后的20/21（logMAR 0.02）（P <.005）。术后平均随访23个月（范围3至48个月）。所有患者均有干眼，3例有结膜瘢痕形成伴轻度角化。无患者术后发生角膜破裂。
结论
通过积极处理干眼和其他眼表问题，白内障手术在GVHD患者中取得了良好的效果。
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