Harty John T, Badovinac Vladimir P
Department of Microbiology, and Interdisciplinary Graduate Program in Immunology, University of Iowa, 3-512 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA.
Curr Opin Immunol. 2002 Jun;14(3):360-5. doi: 10.1016/s0952-7915(02)00333-3.
Expansion and contraction of antigen-specific CD8(+) T cells after infection or vaccination results in stable memory. Recent evidence demonstrates that anti-microbial effector molecules such as perforin and IFN-gamma regulate specific aspects of CD8(+) T cell homeostasis by mechanisms that may be dependent or independent of pathogen clearance.
感染或接种疫苗后，抗原特异性CD8(+) T细胞的扩增和收缩会产生稳定的记忆。最近的证据表明，诸如穿孔素和干扰素-γ等抗微生物效应分子通过可能依赖或不依赖病原体清除的机制来调节CD8(+) T细胞稳态的特定方面。
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