Badovinac V P, Tvinnereim A R, Harty J T
Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA.
Science. 2000 Nov 17;290(5495):1354-8. doi: 10.1126/science.290.5495.1354.
T cell memory depends on factors that regulate expansion and death of these cells after antigenic stimulation. Mice deficient in perforin and interferon-gamma (IFN-gamma) exhibited increased expansion, altered immunodominance, and decreased death of antigen-specific CD8+ T cells after infection with an attenuated strain of Listeria monocytogenes, which was cleared from these mice. Expansion of CD8+ T cells was controlled by perforin, whereas IFN-gamma regulated immunodominance and the death phase. Thus, perforin and IFN-gamma regulate distinct elements of CD8+ T cell homeostasis independently of their role as antimicrobial effector molecules.
T细胞记忆取决于抗原刺激后调节这些细胞增殖和死亡的因素。穿孔素和干扰素-γ（IFN-γ）缺陷的小鼠在感染减毒单核细胞增生李斯特菌后，抗原特异性CD8+T细胞的增殖增加、免疫显性改变且死亡减少，该细菌在这些小鼠体内被清除。CD8+T细胞的增殖由穿孔素控制，而IFN-γ调节免疫显性和死亡阶段。因此，穿孔素和IFN-γ独立于其作为抗菌效应分子的作用，调节CD8+T细胞稳态的不同要素。
