Tsg101：HIV-1的搭乘通行证。
Tsg101: HIV-1's ticket to ride.
作者信息
Carter Carol A
机构信息
Department of Molecular Genetics & Microbiology, Life Sciences Bldg, SUNY at Stony Brook, Stony Brook, NY 11794-5222, USA.
出版信息
Trends Microbiol. 2002 May;10(5):203-5. doi: 10.1016/s0966-842x(02)02350-8.
Abstract
Recent studies implicate the vacuolar protein-sorting pathway in the transport of the retroviral structural precursor (Gag) protein to its budding site on the plasma membrane of infected cells. This exploitation of the cellular endocytic trafficking machinery to release viral particles could lead to the identification of virus-specific modulators and provide opportunities to design new targeted anti-viral agents.
摘要
最近的研究表明，液泡蛋白分选途径参与了逆转录病毒结构前体（Gag）蛋白向受感染细胞质膜上其出芽位点的转运。利用细胞内吞运输机制来释放病毒颗粒，这可能会促成病毒特异性调节剂的鉴定，并为设计新型靶向抗病毒药物提供机会。
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