Celli Jean, Finlay B Brett
Biotechnology Laboratory, University of British Columbia, Room 237, 6174 University Boulevard, Vancouver, BC, Canada V6T 1Z3.
Trends Microbiol. 2002 May;10(5):232-7. doi: 10.1016/s0966-842x(02)02343-0.
Phagocytosis constitutes the primary line of host innate and adaptive defence against incoming microbial pathogens, providing an efficient means for their removal and destruction. However, several virulent bacteria that do not function as intracellular pathogens have evolved mechanisms to avoid and prevent phagocytosis that constitute an essential part of their pathogenic capacity. Some of these mechanisms include preventing recognition by phagocytic receptors or blocking uptake by professional phagocytes. Recently, the molecular mechanisms of such antiphagocytic properties have been elucidated for some pathogens. Such mechanisms illustrate the diversity of mechanisms bacterial pathogens use to avoid phagocytic uptake.
吞噬作用是宿主针对入侵微生物病原体的固有和适应性防御的主要防线，为清除和破坏这些病原体提供了一种有效手段。然而，一些并非细胞内病原体的致病细菌已经进化出避免和防止吞噬作用的机制，这些机制是其致病能力的重要组成部分。其中一些机制包括阻止被吞噬细胞受体识别或阻断专业吞噬细胞的摄取。最近，已经阐明了一些病原体这种抗吞噬特性的分子机制。这些机制说明了细菌病原体用于避免被吞噬摄取的机制的多样性。
