Jordán T, González M, Casado M, Suárez J F, Pulido F, Guerrero E, Esteban J
Servicio de Aparato Digestivo, Hospital Torrecárdenas, Almería, Spain.
Gastroenterol Hepatol. 2002 Apr;25(4):240-3. doi: 10.1016/s0210-5705(02)70252-5.
Amoxicillin-clavulanic acid is a commonly used antibiotic in clinical practice. It is usually prescribed on an empirical basis and several cases of hepatotoxicity with cholestasis have been described. We report the case of a 42-year-old man who developed an acute hepatocellular lesion with progression to cirrhosis. The patient received amoxicillin-clavulanic acid twice with an interval of four months. Other causes of hepatic failure were excluded. Although amoxicillin-clavulanic acid-induced hepatotoxicity has been widely documented, there are no other reports describing its progression to cirrhosis in an adult.
阿莫西林-克拉维酸是临床实践中常用的一种抗生素。它通常是根据经验开出处方，并且已经有几例关于其导致胆汁淤积性肝毒性的病例报道。我们报告了一例42岁男性患者，该患者出现急性肝细胞病变并进展为肝硬化。该患者在间隔四个月的时间里两次服用了阿莫西林-克拉维酸。排除了肝衰竭的其他病因。虽然阿莫西林-克拉维酸引起的肝毒性已有广泛记载，但尚无其他关于其在成人中进展为肝硬化的报道。
