Mazereeuw J, Bonafé J-L
Service de Dermatologie, Hôpital Rangueil, 1, avenue Jean-Poulhès, 31403 Toulouse Cedex.
Ann Dermatol Venereol. 2002 Jan;129(1 Pt 2):137-42.
The clinical characteristic of xerosis is rough or coarse skin. Physiopathologically, the structure of the stratum corneum is modified and abnormalities in keratinization, proliferation, surface lipid, water metabolism and also pH and sebum exist. There are two forms of xerosis: dry skin forms and ichtyosis or ichtyosis-like forms. Xerosis has many etiologies including external aggression, senescence, drugs, infection, atopy, deficiencies, malignant diseases, endocrine affections, eating disorders and renal failure in dialyzed patients. It provokes cutaneous discomfort and unaesthetic appearance that justify appropriate treatment. Treatment is essentially local, symptomatic and must be accompanied by general measures. Many products include moisturizers and emollients (keratolytics: salicylic acid, urea and alpha-hydroxy acid).
皮肤干燥症的临床特征是皮肤粗糙。从生理病理学角度来看,角质层结构发生改变,在角化、增殖、表面脂质、水代谢以及pH值和皮脂方面存在异常。皮肤干燥症有两种形式:干性皮肤形式和鱼鳞病或鱼鳞病样形式。皮肤干燥症有许多病因,包括外部刺激、衰老、药物、感染、特应性、营养缺乏、恶性疾病、内分泌疾病、饮食失调以及透析患者的肾衰竭。它会引起皮肤不适和外观不佳,因此需要进行适当治疗。治疗主要是局部的、对症的,并且必须辅以一般措施。许多产品包括保湿剂和润肤剂(角质松解剂:水杨酸、尿素和α-羟基酸)。