The formation of cytochrome P-450-metabolic intermediate complexes in microsomal fractions from extrahepatic tissues of the rabbit.

Cytochrome P-450-metabolic intermediate complexes were formed from N-hydroxyamphetamine, benzphetamine, norbenzphetamine, and d- and l-amphetamine in lung microsomal fractions and from N-hydroxyamphetamine in small intestinal mucosa microsomal fractions. Complexes were not formed in either tissue from SKF 525-A or propoxyphene. The rates of metabolic intermediate complex formation, per mole of cytochrome P-450, were higher in lung than in liver or small intestine. In contrast to that in liver, metabolic intermediate complex formation in the extrahepatic tissues was not dramatically affected by phenobarbital or 3-methylcholanthrene treatment.