Nijhuis M, Deeks S, Boucher C
Eijkman-Winkler Institute, Department of Virology, University Medical Center, Heidelberglaan, Utrecht, The Netherlands.
Curr Opin Infect Dis. 2001 Feb;14(1):23-8. doi: 10.1097/00001432-200102000-00005.
Treatment of HIV infected patients with antiretroviral drugs often results in the emergence of virus variants with reduced sensitivity to these drugs. However, the viral load often remains partially suppressed below pretherapy levels, which might be explained by a reduced fitness of the drug resistant viral population. This review describes the effects of antiretroviral resistance development on the fitness of the viral population and its clinical implications.
用抗逆转录病毒药物治疗HIV感染患者常常会导致出现对这些药物敏感性降低的病毒变体。然而，病毒载量往往仍会部分抑制在治疗前水平以下，这可能是由于耐药病毒群体适应性降低所致。本综述描述了抗逆转录病毒耐药性的产生对病毒群体适应性的影响及其临床意义。
