Klugman K P, Feldman C
Wits/MRC Pneumococcal Diseases Research Unit, School of Pathology, South African Institute for Medical Research and University of the Witwatersrand, South Africa.
Curr Opin Infect Dis. 2001 Apr;14(2):173-9. doi: 10.1097/00001432-200104000-00011.
This review describes recent contributions to our understanding of pneumococcal pneumonia. Two genes have been described that encode enzymes involved with the biosynthesis of muropeptides. These enzymes may be novel antibiotic targets. The clinical impact of increasing antibiotic resistance on the treatment of pneumonia is the particular focus of the review. As resistant strains are more commonly associated with severe infections in patients with underlying disease, the interpretation of an association of resistance with poor clinical outcome is complicated.
本综述描述了近期对我们理解肺炎球菌肺炎所做的贡献。已描述了两个编码参与胞壁肽生物合成的酶的基因。这些酶可能是新型抗生素靶点。本综述特别关注抗生素耐药性增加对肺炎治疗的临床影响。由于耐药菌株更常与基础疾病患者的严重感染相关，因此对耐药性与不良临床结局之间关联的解读较为复杂。
