Kuloglu Murat, Ustundag Bilal, Atmaca Murad, Canatan Halit, Tezcan A Ertan, Cinkilinc Nadire
Department of Psychiatry, College of Medicine and Firat Medical Center, Firat (Euphrates) University, Elazig, Turkey.
Cell Biochem Funct. 2002 Jun;20(2):171-5. doi: 10.1002/cbf.940.
Recent data from several reports indicate that free radicals are involved in aetiopathogenesis of many human pathologies including neuropsychiatric disorders such as schizophrenia, bipolar disorder etc. In the present study, we aimed at determining and evaluating levels of malondialdehyde (MDA), a product of lipid peroxidation, and antioxidant enzyme superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity levels in patients diagnosed with schizophrenia (n = 25) and bipolar disorder (n = 23). The control group was composed of 20 healthy subjects. There was a significant increase in MDA levels of patients with schizophrenia and bipolar disorder compared with controls. SOD and GSH-Px activity levels were significantly higher in the schizophrenic group compared with controls. SOD activity levels in bipolar the group were significantly higher than controls whereas there were no significant changes in GSH-Px activity levels in the bipolar group and controls. Significant differences between lipid peroxidation product and antioxidant enzyme (SOD and GSH-Px) activity levels in schizophrenic and bipolar disorder patients compared with controls leads us to believe that these differences are related to the heterogenities in aetiologies of these disorders.
近期多项报告的数据表明，自由基参与了包括精神分裂症、双相情感障碍等神经精神疾病在内的多种人类疾病的发病机制。在本研究中，我们旨在测定和评估被诊断为精神分裂症（n = 25）和双相情感障碍（n = 23）患者的脂质过氧化产物丙二醛（MDA）水平以及抗氧化酶超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的活性水平。对照组由20名健康受试者组成。与对照组相比，精神分裂症和双相情感障碍患者的MDA水平显著升高。与对照组相比，精神分裂症组的SOD和GSH-Px活性水平显著更高。双相情感障碍组的SOD活性水平显著高于对照组，而双相情感障碍组和对照组的GSH-Px活性水平无显著变化。与对照组相比，精神分裂症和双相情感障碍患者脂质过氧化产物与抗氧化酶（SOD和GSH-Px）活性水平之间的显著差异使我们相信，这些差异与这些疾病病因的异质性有关。
