Yavo W, Menan E I H, Adjetey T A K, Barro-Kiki P C, Nigué L, Konan Y J, Nebavi N G F, Koné M
Département de parasitologie-mycologie, UFR des sciences pharmaceutiques et biologiques, 01 BPV 34 Abidjan, Côte d'Ivoire.
Pathol Biol (Paris). 2002 Apr;50(3):184-8. doi: 10.1016/s0369-8114(02)00286-9.
A comparative study of the in vivo sensitivity of Plasmodium falciparum to amodiaquine versus chloroquine has been made among children in Agou (south Côte d'Ivoire). In case of resistance to these drugs, the association of sulfadoxine-pyrimethamine was administered and followed by a J14 checking. We have noticed: (1) 8.47% of amodiaquine resistance versus 36.96% of chloroquine resistance (all these resistances are from type II), (2) a good clinical efficiency of the 4 amino quinolines. Only 1.69% of the subjects having resistant stocks to amodiaquine have gone feverish down to J7 whereas 10.47% of subjects have clinically resisted to chloroquine, (3) a good tolerance of drugs and an excellent clinical and parasitological efficiency of the second intention treatment. These data are in favour of using first the 4 amino quinolines (particularly the amodiaquine) in the treatment of simple bout of malaria to Plasmodium falciparum in this region. In case of resistance to these drugs, we recommend the combination sulfadoxine-pyrimethamine.
在阿古（科特迪瓦南部）的儿童中，对恶性疟原虫体内对阿莫地喹与氯喹的敏感性进行了一项比较研究。如果对这些药物产生耐药性，则给予周效磺胺-乙胺嘧啶联合用药，并在第14天进行检查。我们注意到：（1）8.47%的人对阿莫地喹耐药，而36.96%的人对氯喹耐药（所有这些耐药均为II型），（2）4-氨基喹啉类药物具有良好的临床疗效。对阿莫地喹有耐药株的受试者中，只有1.69%在第7天体温下降，而对氯喹临床耐药的受试者中有10.47%，（3）药物耐受性良好，二线治疗具有出色的临床和寄生虫学疗效。这些数据支持在该地区治疗恶性疟原虫引起的单纯性疟疾发作时首先使用4-氨基喹啉类药物（特别是阿莫地喹）。如果对这些药物产生耐药性，我们建议使用周效磺胺-乙胺嘧啶联合用药。
