Johnson-Alvares Dorthea, Cornélissen Germaine, Portela Ana, Halberg Erna, Rudney Joel D, Yeh Chih-Ko, Dodds Michael, Haus Erhard, Schaffer Erwin, Blank Mikhail, Halberg Franz
Department of Community Dentistry, Dental School, University of Texas Health Science Center, San Antonio, TX 78284, USA.
In Vivo. 2002 Jan-Feb;16(1):25-8.
Tumor markers such as CA130 can be determined in human whole saliva. Saliva represents an attractive body fluid for longitudinal studies.
CA130 was determined in parotid saliva from 8 rats fed different diets, with or without autonomic denervation.
CA130 could be determined in parotid saliva of rats, irrespective of diet and/or autonomic denervation. Whether the numerical decrease in CA130 observed after autonomic denervation is statistically significant requires further work.
Since salivary CA130 has been shown to decrease following treatment with anti-cancer drugs in humans, the ability to determine this tumor marker in rat saliva opens new opportunities for optimizing cancer chronotherapy in the experimental laboratory.
