Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets.
作者信息
Johnson-Alvares Dorthea, Cornélissen Germaine, Portela Ana, Halberg Erna, Rudney Joel D, Yeh Chih-Ko, Dodds Michael, Haus Erhard, Schaffer Erwin, Blank Mikhail, Halberg Franz
机构信息
Department of Community Dentistry, Dental School, University of Texas Health Science Center, San Antonio, TX 78284, USA.
出版信息
In Vivo. 2002 Jan-Feb;16(1):25-8.
BACKGROUND
Tumor markers such as CA130 can be determined in human whole saliva. Saliva represents an attractive body fluid for longitudinal studies.
MATERIALS AND METHODS
CA130 was determined in parotid saliva from 8 rats fed different diets, with or without autonomic denervation.
RESULTS
CA130 could be determined in parotid saliva of rats, irrespective of diet and/or autonomic denervation. Whether the numerical decrease in CA130 observed after autonomic denervation is statistically significant requires further work.
CONCLUSIONS
Since salivary CA130 has been shown to decrease following treatment with anti-cancer drugs in humans, the ability to determine this tumor marker in rat saliva opens new opportunities for optimizing cancer chronotherapy in the experimental laboratory.
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