Reimann I, Rasmussen G G
Scand J Rheumatol. 1975;4(4):221-4. doi: 10.3109/03009747509165260.
In 18 rabbits arthritis was induced in one knee joint by injection with 0.2 ml 3% ovalbumin 4 weeks after sensitization by 3% ovalbumin and 2 mg/ml tubercle bacilli suspended in Freunds incomplete adjuvant. Half of the rabbits were treated with Myocrisin 4 mg i.m. once a week during the experimental period lasting 4-5 months. At killing, both knee joints were examined macroscopically and microscopically. In all rabbits a distinct synovitis was found in the injected knee joint. Histologically, the changes were most pronounced in the rabbits not treated with Myocrisin. An activity index of the synovial membrane changes in the Myocrisin-treated and untreated cases was calculated to 6.3 and 3.6 respectively. Some changes were also found in the uninjected knee joints of 50% of the rabbits. In contrast to some other works, this preliminary investigation suggests that antigen-induced experimental arthritis is suppressed by gold. We feel that this model of experimental arthritis may be suitable for trying out the effect of various drugs.
在18只兔子中，在通过将3%卵清蛋白和2mg/ml结核杆菌悬浮于弗氏不完全佐剂中致敏4周后，于一个膝关节内注射0.2ml 3%卵清蛋白诱导关节炎。在持续4至5个月的实验期间，一半兔子每周一次肌肉注射4mg青霉胺。处死时，对两个膝关节进行大体和显微镜检查。在所有兔子中，注射的膝关节均发现明显的滑膜炎。组织学上，未用青霉胺治疗的兔子变化最为明显。计算出青霉胺治疗组和未治疗组滑膜变化的活动指数分别为6.3和3.6。50%的兔子未注射的膝关节也发现了一些变化。与其他一些研究不同，这项初步研究表明金可抑制抗原诱导的实验性关节炎。我们认为这种实验性关节炎模型可能适合用于试验各种药物的效果。
