原位肝移植后同种异体移植感染导致的播散性弓形虫病：定量PCR的作用
Disseminated toxoplasmosis, resulting from infection of allograft, after orthotopic liver transplantation: usefulness of quantitative PCR.
作者信息
Botterel Francoise, Ichai P, Feray C, Bouree P, Saliba F, Tur Raspa R, Samuel D, Romand S
机构信息
Service de Microbiologie, Departement de Parasitologie-Mycologie, Hopital de Bicetre, Faculté de Médecine Paris-Sud, 78 rue du Général Leclerc, 94275 Kremlin-Bicetre Cedex, France.
出版信息
J Clin Microbiol. 2002 May;40(5):1648-50. doi: 10.1128/JCM.40.5.1648-1650.2002.
Abstract
Disseminated toxoplasmosis is a life-threatening disease in liver transplant recipients that can result from an organ-transmitted infection. We report here a case of fatal disseminated toxoplasmosis after orthotopic liver transplantation from a seropositive donor (immunoglobulin G IgG and IgM(-)) in a patient who was nonimmune for toxoplasmosis prior to transplantation. Quantitative PCR analyses of various clinical specimens, including serum samples, appeared retrospectively to be a valuable diagnostic tool that might guide therapeutic attitudes.
摘要
播散性弓形虫病在肝移植受者中是一种危及生命的疾病，可由器官传播感染引起。我们在此报告一例原位肝移植后发生的致命性播散性弓形虫病病例，供者为血清学阳性（免疫球蛋白GIgG且IgM(-)），而受者在移植前对弓形虫病无免疫力。对包括血清样本在内的各种临床标本进行的定量PCR分析，回顾性来看似乎是一种有价值的诊断工具，可能会指导治疗策略。
相似文献
1
Disseminated toxoplasmosis, resulting from infection of allograft, after orthotopic liver transplantation: usefulness of quantitative PCR.原位肝移植后同种异体移植感染导致的播散性弓形虫病：定量PCR的作用
J Clin Microbiol. 2002 May;40(5):1648-50. doi: 10.1128/JCM.40.5.1648-1650.2002.
2
[Development of a real-time PCR assay for quantitative diagnosis of Toxoplasma gondii after allogeneic bone marrow transplantation].[一种用于异基因骨髓移植后弓形虫定量诊断的实时荧光定量PCR检测方法的建立]
Pathol Biol (Paris). 2010 Feb;58(1):104-9. doi: 10.1016/j.patbio.2009.07.013. Epub 2009 Nov 4.
3
Incidence and diagnosis of active toxoplasma infection among liver transplant recipients in Western Turkey.土耳其西部肝移植受者中活动性弓形虫感染的发病率与诊断
Liver Transpl. 2008 Oct;14(10):1526-32. doi: 10.1002/lt.21558.
4
Fatal disseminated toxoplasmosis in a cardiac transplantation with seropositive match for Toxoplasma: should prophylaxis be extended?心脏移植中与弓形虫血清学阳性匹配的致命播散性弓形虫病：预防性治疗是否应扩大？
Transpl Immunol. 2007 Nov;18(2):193-7. doi: 10.1016/j.trim.2007.05.016. Epub 2007 Jun 14.
5
Correlation of parasite load determined by quantitative PCR to clinical outcome in a heart transplant patient with disseminated toxoplasmosis.定量 PCR 检测的寄生虫载量与心脏移植患者播散性弓形虫病临床结局的相关性。
J Clin Microbiol. 2010 Jul;48(7):2541-5. doi: 10.1128/JCM.00252-10. Epub 2010 May 12.
6
A prospective study of diagnosis of Toxoplasma gondii infection after bone marrow transplantation.骨髓移植后弓形虫感染诊断的前瞻性研究。
APMIS. 2008 May;116(5):345-51. doi: 10.1111/j.1600-0463.2008.00871.x.
7
Molecular diagnosis of Toxoplasma gondii infection in Libya.利比亚弓形虫感染的分子诊断
BMC Infect Dis. 2016 Apr 16;16:157. doi: 10.1186/s12879-016-1491-5.
8
[Retrospective study of the implementation of the qualitative PCR technique in biological samples for monitoring toxoplasmosis in pediatric patients receiving hematopoietic stem cell transplantation].[对接受造血干细胞移植的儿科患者生物样本中定性PCR技术用于监测弓形虫病实施情况的回顾性研究]
Rev Argent Microbiol. 2014 Jan-Mar;46(1):24-9. doi: 10.1016/S0325-7541(14)70043-4.
9
Acute Liver Failure Due to Toxoplasmosis After Orthotopic Liver Transplantation.肝移植术后弓形虫感染致急性肝衰竭
J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211014691. doi: 10.1177/23247096211014691.
10
Early detection of Toxoplasma infection by molecular monitoring of Toxoplasma gondii in peripheral blood samples after allogeneic stem cell transplantation.异基因造血干细胞移植后通过对外周血样本中的刚地弓形虫进行分子监测来早期检测弓形虫感染。
Clin Infect Dis. 2005 Jan 1;40(1):67-78. doi: 10.1086/426447. Epub 2004 Dec 7.
引用本文的文献
1
Toxoplasmosis-Associated Hemophagocytic Lymphohistiocytosis in a Liver Transplant Recipient.肝移植受者中的弓形虫病相关噬血细胞性淋巴组织细胞增生症
Cureus. 2024 Oct 19;16(10):e71843. doi: 10.7759/cureus.71843. eCollection 2024 Oct.
2
Effective factors in the pathogenesis of .……发病机制中的有效因素。
你提供的原文不完整，“of”后面缺少具体内容。
Heliyon. 2024 May 19;10(10):e31558. doi: 10.1016/j.heliyon.2024.e31558. eCollection 2024 May 30.
3
Prevalence of 36-KDa antigen and chronic Hepatitis C: another evidence of an Association.36千道尔顿抗原与慢性丙型肝炎的患病率：关联的又一证据
J Parasit Dis. 2021 Dec;45(4):1049-1054. doi: 10.1007/s12639-021-01351-8. Epub 2021 May 6.
4
Multicentric Evaluation of the Bio-Evolution Toxoplasma gondii Assay for the Detection of DNA in Immunocompromised Patients.多中心评估 Bio-Evolution Toxoplasma gondii 检测试剂盒用于免疫功能低下患者 DNA 的检测。
J Clin Microbiol. 2020 Jan 28;58(2). doi: 10.1128/JCM.01231-19.
5
Prevalence of Antibodies and DNA in Iranian HIV Patients.伊朗艾滋病患者中抗体和DNA的流行情况。
Iran J Pathol. 2019 Winter;14(1):68-75. doi: 10.30699/IJP.14.1.68. Epub 2018 Dec 27.
6
Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission.实体器官移植中的传染病传播：供体评估、受体风险及传播结果
Transplant Direct. 2018 Dec 20;5(1):e416. doi: 10.1097/TXD.0000000000000852. eCollection 2019 Jan.
7
Frequency of sero-positivity in household members of the patients with positive toxoplasma serology.弓形虫血清学阳性患者家庭成员中血清阳性的频率。
Rev Esp Quimioter. 2018 Dec;31(6):506-510. Epub 2018 Oct 26.
8
Solid Organ Transplant and Parasitic Diseases: A Review of the Clinical Cases in the Last Two Decades.实体器官移植与寄生虫病：过去二十年临床病例综述
Pathogens. 2018 Jul 31;7(3):65. doi: 10.3390/pathogens7030065.
9
Molecular diagnosis of toxoplasmosis in immunocompromised patients: a 3-year multicenter retrospective study.免疫功能低下患者弓形虫病的分子诊断：一项为期3年的多中心回顾性研究。
J Clin Microbiol. 2015 May;53(5):1677-84. doi: 10.1128/JCM.03282-14. Epub 2015 Mar 11.
10
Frequency of Toxoplasma gondii in HIV Positive Patients from West of Iran by ELISA and PCR.伊朗西部HIV阳性患者弓形虫感染率的ELISA和PCR检测
Iran J Parasitol. 2014 Oct-Dec;9(4):474-81.
本文引用的文献
1
Quantitative detection of Toxoplasma gondii DNA in human body fluids by TaqMan polymerase chain reaction.应用TaqMan聚合酶链反应定量检测人体体液中的弓形虫DNA
Clin Microbiol Infect. 2001 Mar;7(3):120-4. doi: 10.1046/j.1469-0691.2001.00224.x.
2
Real-time PCR for quantitative detection of Toxoplasma gondii.用于定量检测弓形虫的实时聚合酶链反应
J Clin Microbiol. 2000 Nov;38(11):4121-5. doi: 10.1128/JCM.38.11.4121-4125.2000.
3
Real-time PCR for diagnosis and follow-up of Toxoplasma reactivation after allogeneic stem cell transplantation using fluorescence resonance energy transfer hybridization probes.使用荧光共振能量转移杂交探针的实时聚合酶链反应用于异基因干细胞移植后弓形虫再激活的诊断和随访
J Clin Microbiol. 2000 Aug;38(8):2929-32. doi: 10.1128/JCM.38.8.2929-2932.2000.
4
Disseminated toxoplasmosis after liver transplantation.
Clin Infect Dis. 1999 Sep;29(3):705-6. doi: 10.1086/598673.
5
Disseminated toxoplasmosis after liver transplantation: case report and review.
Clin Infect Dis. 1998 Nov;27(5):1327-8.
6
Toxoplasma gondii pneumonitis in a liver transplant recipient: implications for diagnosis.肝移植受者的弓形虫肺炎：对诊断的启示
Liver Transpl Surg. 1996 Jul;2(4):299-300. doi: 10.1002/lt.500020408.
7
Toxoplasmosis in kidney transplant recipients: report of six cases and review.肾移植受者的弓形虫病：6例报告及文献复习
Clin Infect Dis. 1997 Apr;24(4):625-34. doi: 10.1093/clind/24.4.625.
8
The LightCycler: a microvolume multisample fluorimeter with rapid temperature control.罗氏LightCycler荧光定量PCR仪：一款具备快速温度控制功能的微量多样品荧光计。
Biotechniques. 1997 Jan;22(1):176-81. doi: 10.2144/97221pf02.
9
Perioperative respiratory management with fiberoptic bronchoscopy in pediatric living-related liver transplantation.
Surgery. 1996 Feb;119(2):198-201. doi: 10.1016/s0039-6060(96)80169-3.
10
Transmission of Toxoplasma gondii infection by liver transplantation.肝移植导致的弓形虫感染传播
Clin Infect Dis. 1995 Sep;21(3):511-5. doi: 10.1093/clinids/21.3.511.
Zotero 插件