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Pro/con clinical debate: are steroids useful in the management of patients with septic shock?正反临床辩论:类固醇在感染性休克患者的治疗中是否有用?
Crit Care. 2002 Apr;6(2):113-6. doi: 10.1186/cc1467. Epub 2002 Feb 6.
2
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[Corticotherapy in severe infectious states].[重度感染状态下的皮质激素治疗]
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Use of corticosteroids in septic shock.脓毒性休克中糖皮质激素的应用。
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Crit Care Med. 2010 Jan;38(1):338; authore reply 338-9. doi: 10.1097/CCM.0b013e3181bc7ab8.
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The International Sepsis Forum's controversies in sepsis: corticosteroids should not be routinely used to treat septic shock.国际脓毒症论坛关于脓毒症的争议:不应常规使用皮质类固醇治疗感染性休克。
Crit Care. 2002 Oct;6(5):384-6. doi: 10.1186/cc1531. Epub 2002 Jul 17.

本文引用的文献

1
The hypothalamic-pituitary-adrenal axis of patients with severe sepsis: altered response to corticotropin-releasing hormone.严重脓毒症患者的下丘脑-垂体-肾上腺轴:对促肾上腺皮质激素释放激素的反应改变
Crit Care Med. 2001 Feb;29(2):310-6. doi: 10.1097/00003246-200102000-00017.
2
Efficacy and safety of recombinant human activated protein C for severe sepsis.重组人活化蛋白C治疗严重脓毒症的疗效与安全性
N Engl J Med. 2001 Mar 8;344(10):699-709. doi: 10.1056/NEJM200103083441001.
3
Severe sepsis and septic shock. Definitions, epidemiology, and clinical manifestations.严重脓毒症和脓毒性休克。定义、流行病学及临床表现。
Crit Care Clin. 2000 Apr;16(2):179-92. doi: 10.1016/s0749-0704(05)70106-8.
4
Beta-blocker therapy for heart failure: the evidence is in, now the work begins.β受体阻滞剂治疗心力衰竭:证据已明,现在工作开始。
JAMA. 2000 Mar 8;283(10):1335-7. doi: 10.1001/jama.283.10.1335.
5
A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin.基于皮质醇水平及皮质醇对促肾上腺皮质激素反应的脓毒性休克三级预后分类
JAMA. 2000 Feb 23;283(8):1038-45. doi: 10.1001/jama.283.8.1038.
6
The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder and health-related quality of life in survivors.
Crit Care Med. 1999 Dec;27(12):2678-83. doi: 10.1097/00003246-199912000-00012.
7
Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study.应激剂量氢化可的松可逆转高动力型感染性休克:一项前瞻性、随机、双盲、单中心研究。
Crit Care Med. 1999 Apr;27(4):723-32. doi: 10.1097/00003246-199904000-00025.
8
Reversal of late septic shock with supraphysiologic doses of hydrocortisone.用超生理剂量氢化可的松逆转晚期感染性休克
Crit Care Med. 1998 Apr;26(4):645-50. doi: 10.1097/00003246-199804000-00010.
9
Corticosteroids in septic shock: resurrection of the last rites?脓毒性休克中的皮质类固醇:最后的仪式要复活了?
Crit Care Med. 1998 Apr;26(4):627-30. doi: 10.1097/00003246-199804000-00002.
10
Corticosteroid therapy in severe illness.重症疾病中的皮质类固醇治疗。
N Engl J Med. 1997 Oct 30;337(18):1285-92. doi: 10.1056/NEJM199710303371807.

正反临床辩论:类固醇在感染性休克患者的治疗中是否有用?

Pro/con clinical debate: are steroids useful in the management of patients with septic shock?

作者信息

Ritacca Frank V, Simone Carmine, Wax Randy, Craig Katherine G, Walley Keith R

机构信息

Resident, Department of Medicine, University of Toronto, Canada.

出版信息

Crit Care. 2002 Apr;6(2):113-6. doi: 10.1186/cc1467. Epub 2002 Feb 6.

DOI:10.1186/cc1467
PMID:11983034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC137290/
Abstract

Decision-making in the intensive care unit is often very difficult. Although we are encouraged to make evidence-based decisions, this may be difficult for a number of reasons. To begin with, evidence may not exist to answer the clinical question. Second, when there is evidence it may not be applicable to the patient in question or the clinician may be reluctant to apply it to the patient based on a number of secondary issues such as costs, premorbid condition or possible complications. Finally, emotions are often highly charged when caring for patients that have a significant chance of death, and care-givers as well as families are frequently prepared to take chances on a therapy whose benefit is not entirely clear. Steroid use in septic shock is an example of a therapy that makes some sense but has conflicting support in the literature. In this issue of Critical Care Forum, the two sides of this often heated debate are brought to the forefront in an interesting format.

摘要

重症监护病房中的决策往往非常困难。尽管我们被鼓励做出基于证据的决策,但由于多种原因,这可能很难做到。首先,可能不存在回答临床问题的证据。其次,当有证据时,它可能不适用于相关患者,或者临床医生可能基于一些次要问题(如成本、病前状况或可能的并发症)而不愿将其应用于患者。最后,在护理有很大死亡风险的患者时,情绪往往高度紧张,护理人员和家属经常愿意冒险采用一种益处并不完全明确的治疗方法。在感染性休克中使用类固醇就是一种有一定道理但在文献中支持观点相互矛盾的治疗方法的例子。在本期《重症监护论坛》中,这场常常激烈的辩论的双方以一种有趣的形式被呈现在了最前沿。