Kanoh Hideo, Yamada Keiko, Sakane Fumio
Department of Biochemistry, School of Medicine, Sapporo Medical University, South-West-17, Sapporo 060-8556, Japan.
J Biochem. 2002 May;131(5):629-33. doi: 10.1093/oxfordjournals.jbchem.a003144.
Diacylglycerol kinase (DGK) regulates signal transduction by modulating the balance between the two signaling lipids, diacylglycerol and phosphatidic acid. DGK and its homologs occur in a wide range of multicellular organisms and the mammalian DGK is known to consist of nine members with a considerable incidence of alternative splicing. Recent work has established that DGK serves as a key attenuator of diacylglycerol of signaling functions and that the mammalian isozymes are equipped with molecular machineries which enable them to act in specific intracellular sites and/or in signaling protein complexes.
二酰基甘油激酶（DGK）通过调节两种信号脂质二酰基甘油和磷脂酸之间的平衡来调控信号转导。DGK及其同源物存在于多种多细胞生物中，已知哺乳动物的DGK由九个成员组成，且存在相当比例的可变剪接。最近的研究表明，DGK是信号功能中二酰基甘油的关键衰减因子，并且哺乳动物同工酶配备有分子机制，使其能够在特定的细胞内位点和/或信号蛋白复合物中发挥作用。
