T淋巴细胞中的核激素受体
Nuclear hormone receptors in T lymphocytes.
作者信息
Winoto Astar, Littman Dan R
机构信息
Department of Molecular and Cell Biology, 469 LSA, University of California, Berkeley, Berkeley, CA 94720, USA.
出版信息
Cell. 2002 Apr;109 Suppl:S57-66. doi: 10.1016/s0092-8674(02)00710-9.
Abstract
Among the numerous steroid and orphan nuclear receptors encoded within mammalian genomes, several are involved in regulating immune system functions. We review here recent studies on the glucocorticoid receptor and the orphan receptors Nur77 and RORgamma. These molecules play key roles in the development and the effector functions of T lymphocytes.
摘要
在哺乳动物基因组编码的众多类固醇和孤儿核受体中，有几种参与调节免疫系统功能。我们在此综述糖皮质激素受体以及孤儿受体Nur77和RORγ的近期研究。这些分子在T淋巴细胞的发育和效应功能中发挥关键作用。
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