Schrag A, Keens J, Warner J
Department of Clinical Neurology, Institute of Neurology, London, UK.
Eur J Neurol. 2002 May;9(3):253-7. doi: 10.1046/j.1468-1331.2002.00392.x.
The effect of Ropinirole on tremor in early Parkinson's disease (PD) was assessed. The results of three multicentre, randomized, double-blind trials comparing ropinirole monotherapy with levodopa, bromocriptine and placebo treatment were analysed retrospectively with respect to improvement of resting tremor and postural/action tremor as measured by items 20 and 21 of the motor section of the Unified Parkinson's Disease Rating Scale (UPDRS). Improvements in resting tremor were significantly better with ropinirole than placebo. There were no significant differences between the effect of ropinirole and those of levodopa (L-dopa) or bromocriptine on resting tremor. Postural/action tremor was mild in these early therapy studies, and there were no significant differences between treatment groups. These results suggest that ropinirole monotherapy is effective in treating resting tremor in early PD. On the other hand, response of postural/action tremor to dopaminergic treatment in early PD was not significantly better than to placebo at the dosages used in these trials.
评估了罗匹尼罗对早期帕金森病（PD）震颤的影响。回顾性分析了三项多中心、随机、双盲试验的结果，这些试验比较了罗匹尼罗单药治疗与左旋多巴、溴隐亭和安慰剂治疗，依据统一帕金森病评定量表（UPDRS）运动部分第20项和第21项所测量的静止性震颤和姿势性/动作性震颤的改善情况。罗匹尼罗治疗静止性震颤的改善效果显著优于安慰剂。罗匹尼罗与左旋多巴（L-多巴）或溴隐亭对静止性震颤的疗效无显著差异。在这些早期治疗研究中，姿势性/动作性震颤较轻，各治疗组之间无显著差异。这些结果表明，罗匹尼罗单药治疗对早期PD的静止性震颤有效。另一方面，在这些试验所使用的剂量下，早期PD中姿势性/动作性震颤对多巴胺能治疗的反应并不显著优于安慰剂。
