[两例霍奇金病患者伴进行性胆管减少的特发性胆汁淤积]
[Idiopathic cholestasis associated with progressive ductopenia in two patients with hodgkin's disease].
作者信息
Ripoll C, Carretero L, Sabin P, Alvarez E, Marrupe D, Bañares R
机构信息
Servicio de Medicina de Aparato Digestivo. Hospital General Universitario Gregorio Marañón. Madrid. Spain.
出版信息
Gastroenterol Hepatol. 2002 May;25(5):313-5. doi: 10.1016/s0210-5705(02)79026-2.
INTRODUCTION
Jaundice in Hodgkin's disease can be due to several causes. Ductal lesions and ductopenia, which we describe below, have rarely been reported.
CASE REPORT
We describe 2 cases of idiopathic cholestasis associated with Hodgkin's disease in which duction lesions and ductopenia were found. In one case, the ductal lesion progressed to ductopenia and the patient died from complications of her oncological disease while in the second case, outcome was favorable with improvement of cholestasis and remission of Hodgkin's lymphoma.
DISCUSSION
Ductopenia should be included in the differential diagnosis of cholestasis associated with Hodgkin's disease, for which a high degree of suspicion is required. Hodgkin's disease should be suspected when ductopenia is found.
引言
霍奇金淋巴瘤中的黄疸可能由多种原因引起。我们在下文描述的导管病变和小胆管减少症很少被报道。
病例报告
我们描述了2例与霍奇金淋巴瘤相关的特发性胆汁淤积病例，其中发现了导管病变和小胆管减少症。1例中，导管病变进展为小胆管减少症，患者死于肿瘤疾病并发症；而在第2例中，胆汁淤积得到改善，霍奇金淋巴瘤缓解，预后良好。
讨论
小胆管减少症应纳入与霍奇金淋巴瘤相关的胆汁淤积的鉴别诊断中，对此需要高度怀疑。当发现小胆管减少症时应怀疑霍奇金淋巴瘤。
Zotero 插件