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Synthesis and anticonvulsant activity of some omega-(1H-1-imidazolyl)-N-phenylalkanoic acid amide derivatives.

作者信息

Aktürk Zeynep, Kiliç Fatma, Erol Kevser, Pabuçcuoğlu Varol

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University Bornova, Izmir, Turkey.

出版信息

Farmaco. 2002 Mar;57(3):201-6. doi: 10.1016/s0014-827x(01)01197-1.

DOI:10.1016/s0014-827x(01)01197-1
PMID:11989798
Abstract

In this study, 15 omega-(1H-imidazol-1-yl)-N-phenylacetamide, propionamide and butyramide derivatives having methoxyl, methyl, nitro and chloro in ortho position of N-phenyl ring or without any substituent have been realized by two-step synthesis. Their anticonvulsant activity was determined against seizures induced by maximal electroshock (MES). The most active compound in the series was 2-(1H-imidazol-1-yl)-N-(o-chlorophenyl)acetamide.

摘要

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