McDonough-Ryan Patricia, DelBello Melissa, Shear Paula K, Ris Douglas M, Soutullo Ceasar, Strakowski Stephen M
Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH, USA.
J Clin Exp Neuropsychol. 2002 May;24(3):280-5. doi: 10.1076/jcen.24.3.280.980.
It has been hypothesized that children who are at genetic risk to develop bipolar disorder demonstrate deficiencies consistent with the syndrome of nonverbal learning disabilities (NLD); however, this hypothesis has never been tested directly. In the present study, a group of at-risk children (AR group; N = 28) was compared to a demographically matched control group of children of healthy parents (HC group; N = 24) for evidence of a constellation of features associated with NLD. Some characteristic features of NLD were evident, including significant Verbal IQ (VIQ) > Performance IQ (PIQ) discrepancies and psychomotor deficits. However, academic deficiencies in mechanical arithmetic relative to reading and spelling abilities were not demonstrated. These findings replicate and extend the current literature on the cognitive functioning of children of parents with Bipolar disorder (BPD). The results, however, do not support the presence of NLD in these children.
有假说认为，有患双相情感障碍遗传风险的儿童表现出与非言语学习障碍（NLD）综合征相符的缺陷；然而，这一假说从未得到直接验证。在本研究中，将一组有风险的儿童（AR组；N = 28）与一组在人口统计学上匹配的健康父母的儿童对照组（HC组；N = 24）进行比较，以寻找与NLD相关的一系列特征的证据。NLD的一些特征很明显，包括显著的言语智商（VIQ）>操作智商（PIQ）差异和心理运动缺陷。然而，相对于阅读和拼写能力，在机械算术方面的学业缺陷并未得到证实。这些发现重复并扩展了目前关于双相情感障碍（BPD）患者子女认知功能的文献。然而，结果并不支持这些儿童存在NLD。
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