Müller S, Felsch G, Kröhne H J, Hanzl G
Z Gesamte Inn Med. 1975 Jun 15;30(12):89-91.
In 152 patients with diabetes mellitus, chronic ischaemic heart diseases and hypertension the so-called ptf-product resulting from the height of the amplitude of P and its time of spreading) measured in the lead V1 (PV1-index), was determined and compared with the values of 93 persons with healthy heart. Patients of the groups of diseases mentioned showed significantly higher pathological values than persons with healthy heart (limiting value -0.02 mms). A comparison between patients with chromic ischaemic heart disease at the age of 36-55 years and a group of diabetics of the same age without the clinical signs of an ischaemic heart disease resulted in no statistically ascertained differences. But compared with a group of persons with healthy heart of the same age the groups clearly differed: 63.9% of pathological values in the total group of disease compared with 18.5% of pathological values in persons with healthy heart. In 137 patients with latent diabetes (protodiabetes) in 54.7% also pathological ptf-values were found. It is possible that the determination of the ptf-product is able to ascertain already early forms of a chronic ischaemic heart disease still before its clinical manifestation. The large number of pathological values in patients with protodiabetes could be a first reference to early beginning disturbances of the left-sided atrial activity in the sense of a microangiopathy.
在152例患有糖尿病、慢性缺血性心脏病和高血压的患者中，测定了在V1导联中测量的由P波振幅高度及其传播时间得出的所谓ptf乘积（PV1指数），并与93名心脏健康者的值进行比较。上述疾病组的患者显示出比心脏健康者明显更高的病理值（临界值为-0.02毫米秒）。对36至55岁的慢性缺血性心脏病患者与一组同龄且无缺血性心脏病临床体征的糖尿病患者进行比较，未发现统计学上确定的差异。但与同龄的心脏健康者组相比，这两组明显不同：疾病总组中63.9%的病理值，而心脏健康者中为18.5%。在137例潜伏性糖尿病（糖尿病前期）患者中，也有54.7%发现了病理ptf值。有可能ptf乘积的测定能够在慢性缺血性心脏病临床表现之前就确定其早期形式。糖尿病前期患者中大量的病理值可能首先提示在微血管病变意义上左侧心房活动的早期开始紊乱。
