Mansingh A, Sawh D M
Division of Orthopaedics, Department of Surgery, Radiology, Anaesthesia and Intensive Care, University of the West Indies, Kingston 7, Jamaica.
West Indian Med J. 2001 Dec;50(4):309-12.
Empirical antibiotic treatment for hand infections is changing to single antibiotic therapy against Staphylococcus aureus in immunocompetent patients. Fifty-one patients treated surgically for hand infections were reviewed to assess the nature of infection in terms of site, organism, mechanism of injury, and antibiotic sensitivity of the organisms. Twenty-three per cent of patients had diabetes mellitus and were noted to be older than non-diabetics. Eighty-four per cent of non-diabetic patients had single organism infections, 59% involving S aureus. Fifty per cent of diabetic patients had multi-organism infection caused by gram positive and gram negative organisms. Patients stuck with a piece of wood also had multi-organism infections. Double antibiotic therapy is therefore advocated for patients with diabetes mellitus and all patients who had hand infections as a result of being stuck with a piece of wood. All others should have single antibiotic therapy with amoxycillin and clavulanic acid.
对于免疫功能正常的手部感染患者,经验性抗生素治疗正转变为针对金黄色葡萄球菌的单一抗生素疗法。对51例接受手部感染手术治疗的患者进行了回顾,以根据感染部位、病原体、损伤机制和病原体的抗生素敏感性评估感染的性质。23%的患者患有糖尿病,且被发现比非糖尿病患者年龄更大。84%的非糖尿病患者为单一病原体感染,其中59%涉及金黄色葡萄球菌。50%的糖尿病患者有由革兰氏阳性菌和革兰氏阴性菌引起的多病原体感染。被木头刺伤的患者也有多病原体感染。因此,对于糖尿病患者以及所有因被木头刺伤而发生手部感染的患者,提倡采用双重抗生素治疗。其他所有患者应使用阿莫西林和克拉维酸进行单一抗生素治疗。