The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.
作者信息
Chua Katrin F, Alt Frederick W, Manis John P
机构信息
Howard Hughes Medical Institute and Children's Hospital, Center for Blood Research and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
出版信息
J Exp Med. 2002 May 6;195(9):F37-41. doi: 10.1084/jem.20020380.
Abstract
摘要
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本文引用的文献
1
Pillars Article: Origin of antibody variation. Nature 1966. 211: 242-243.
J Immunol. 2006 Oct 1;177(7):4237-8.
2
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J Exp Med. 2002 May 6;195(9):1193-8. doi: 10.1084/jem.20011858.
3
DNA double-strand breaks: prior to but not sufficient in targeting hypermutation.
J Exp Med. 2002 May 6;195(9):1187-92. doi: 10.1084/jem.20011749.
4
IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells.
Immunity. 2002 Apr;16(4):607-17. doi: 10.1016/s1074-7613(02)00306-0.
5
AID is essential for immunoglobulin V gene conversion in a cultured B cell line.
Curr Biol. 2002 Mar 5;12(5):435-8. doi: 10.1016/s0960-9822(02)00717-0.
6
The AID enzyme induces class switch recombination in fibroblasts.
Nature. 2002 Mar 21;416(6878):340-5. doi: 10.1038/nature727. Epub 2002 Mar 3.
7
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8
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Science. 2002 Feb 15;295(5558):1301-6. doi: 10.1126/science.1067308.
9
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Nature. 2002 Feb 14;415(6873):802-6. doi: 10.1038/nature714. Epub 2002 Jan 30.
10
Mechanism and control of class-switch recombination.
Trends Immunol. 2002 Jan;23(1):31-9. doi: 10.1016/s1471-4906(01)02111-1.
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