Renno Toufic, Wilson Anne, Dunkel Caroline, Coste Isabelle, Maisnier-Patin Karine, Benoit de Coignac Amélie, Aubry Jean-Pierre, Lees Rosemary K, Bonnefoy Jean-Yves, MacDonald H Robson, Gauchat Jean-François
Centre d'Immunologie Pierre Fabre, 5 Avenue Napoleon III, Saint-Julien en Genevois, 74160 France.
J Immunol. 2002 May 15;168(10):4946-50. doi: 10.4049/jimmunol.168.10.4946.
We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCRbeta selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells.
我们之前鉴定出一种单克隆抗体（mAb），它能与在循环胸腺细胞表面优先表达的一种分子结合。在本研究中，通过表达克隆已在小鼠体内将这种单克隆抗体识别的分子鉴定为CD147（基底膜蛋白）。我们发现，即使在没有TCRβ选择的情况下，CD147的表达也与未成熟胸腺细胞的循环相关，并且在未成熟胎儿胸腺细胞上连接该分子会抑制它们进一步发育为成熟T细胞。
