Masuda Takako, Yamada Hirohide, Takada Kaori, Sagata Yasufumi, Yamaguchi Mikiyo, Tomiyama Yoshinobu, Oshita Shuzo
Department of Anesthesiology, Tokushima University School of Medicine, Tokushima 770-8503.
Masui. 2002 Apr;51(4):394-9.
Bispectral index (BIS) is a processed EEG parameter for assessment of hypnotic effects of anesthetics. We studied whether BIS monitoring can improve recovery from propofol anesthesia and decrease the total amount of propofol needed. Forty-six patients without hypertension and obesity were studied. In the BIS group (n = 20), propofol infusion rate was adjusted to achieve a target BIS value between 40-60, increasing to 65 during the final 10 min of the surgical procedure. In the control group (n = 19), propofol infusion rate was adjusted based only on standard clinical signs. Compared with the control group, patients in the BIS group required lower propofol infusion rates(4.3 +/- 1.1 vs 4.9 +/- 0.8 mg.kg-1.h-1; P < 0.05), and the total amount of propofol decreased significantly (709 +/- 210 vs 914 +/- 326 mg; P < 0.05). BIS monitoring led to immediate recovery after propofol anesthesia. There were no significant differences in the incidence of intraoperative responses between the two groups. BIS monitoring decreased the total amount of propofol and led to immediate recovery after propofol anesthesia. These findings indicate that the use of BIS monitoring may be useful in controlling the infusion rate of propofol during surgery.
脑电双频指数（BIS）是一种经过处理的脑电图参数，用于评估麻醉药的催眠效果。我们研究了BIS监测是否能改善丙泊酚麻醉后的恢复情况并减少所需丙泊酚的总量。对46例无高血压和肥胖症的患者进行了研究。在BIS组（n = 20）中，调整丙泊酚输注速率以达到40 - 60的目标BIS值，在手术最后10分钟将其提高到65。在对照组（n = 19）中，仅根据标准临床体征调整丙泊酚输注速率。与对照组相比，BIS组患者所需的丙泊酚输注速率较低（4.3±1.1 vs 4.9±0.8 mg·kg⁻¹·h⁻¹；P < 0.05），丙泊酚总量显著减少（709±210 vs 914±326 mg；P < 0.05）。BIS监测导致丙泊酚麻醉后立即恢复。两组术中反应发生率无显著差异。BIS监测减少了丙泊酚总量，并导致丙泊酚麻醉后立即恢复。这些发现表明，使用BIS监测可能有助于在手术期间控制丙泊酚的输注速率。
