Satomoto Maiko, Adachi Yushi, Higuchi Hideyuki, Watanabe Kazuhiko, Satoh Tetsuo
Medical Corps, 1st Wings, Japan Air Self Defense Force, Hamamatsu 432-8551.
Masui. 2002 Apr;51(4):431-4.
A method for gas chromatograph-mass spectrometric assay has been developed for the quantitation of flurbiprofen in human plasma. Extraction or condensing procedure was not required and the method reduced time involved in sample preparation. The analytes were separated on the fused-silica capillary column. The operating conditions were: injector, 250 degrees C; detector, 300 degrees C; and column, 50-280 degrees C. The total gas flow-rate of helium (carrier) was 50 ml.min-1 and the pressure of column inlet was 100-200 kPa. The retention time was 18.1 min and the limit of quantitation was 0.5 microgram.ml-1. This method provides an easy and simple method for the detection of flurbiprofen.
已开发出一种气相色谱 - 质谱分析法用于定量测定人血浆中的氟比洛芬。该方法无需萃取或浓缩步骤，减少了样品制备所需的时间。分析物在熔融石英毛细管柱上分离。操作条件为：进样口温度250℃；检测器温度300℃；柱温50 - 280℃。氦气（载气）总流速为50 ml·min⁻¹，柱入口压力为100 - 200 kPa。保留时间为18.1分钟，定量限为0.5微克·ml⁻¹。该方法为氟比洛芬的检测提供了一种简便易行的方法。
