Joly-Guillou M L, Hidri N, Wolff M
Hôpital Louis-Mourier, service de microbiologie, 178, rue des Renouilliers, 92701 Colombes.
Presse Med. 2002 Apr 13;31(14):651-6.
The increasing importance of Acinetobacter as a nosocomial pathogen responsible for outbreaks in intensive care units has been pointed out for twenty years. Today Acinetobacter infections are essentially pneumonia in patients under mechanical ventilation.
Most clinical isolates are resistant to b-lactam antibiotics as well as to other drugs. Animal models represent an essential step between in vivo testing an<d clinical studies, necessary to understand physiopathology, pharmacology and efficacy of therapy. The virulence of clinical isolates of Acinetobacter spp has been studied in a mouse model of systemic infection. Pharmacological studies and efficacy of antibiotics have been studied in a mouse model of Acinetobacter pneumonia.
The majority of strains are multi-resistant to antibiotics and the infections they cause are difficult to treat. Isolated or combined Sulbactam has often been used with success.
二十年来，不动杆菌作为重症监护病房爆发疫情的医院病原体，其重要性日益凸显。如今，不动杆菌感染主要发生在接受机械通气的患者身上，表现为肺炎。
大多数临床分离株对β-内酰胺类抗生素以及其他药物耐药。动物模型是体内试验和临床研究之间的重要环节，对于理解生理病理学、药理学和治疗效果至关重要。已在全身性感染的小鼠模型中研究了不动杆菌属临床分离株的毒力。在不动杆菌肺炎小鼠模型中研究了抗生素的药理学和疗效。
大多数菌株对多种抗生素耐药，它们引起的感染难以治疗。单独或联合使用舒巴坦常常取得成功。
