Mumby Dave G, Glenn Melissa J, Nesbitt Catherine, Kyriazis Diana A
Center for Studies in Behavioral Neurobiology, Department of Psychology, DS-413, Concordia University, 7141 Sherbrooke St. W., Montreal, Que., Canada H4B 1R6.
Behav Brain Res. 2002 May 14;132(2):215-26. doi: 10.1016/s0166-4328(01)00444-2.
This experiment examined the effects of perirhinal cortex (PeRh) lesions on rats' retrograde memory for object-discriminations and retrograde object recognition. Rats learned one discrimination problem or five concurrent discrimination problems 4 weeks before surgery, and a new problem or five new problems during the week preceding surgery. Each rat was also familiarized with a sample object in an open field, 5, 3, or 1 week before surgery. PeRh-lesioned rats displayed normal retention of the object discrimination problems, but on a test of novelty preference they showed evidence of impaired recognition of the sample objects. A similar dissociation was observed on anterograde tests of object-discrimination learning and object recognition. The findings suggest the perirhinal cortex plays an essential role in rats' ability to discriminate the familiarity of objects previously encountered either before or after surgery, but this ability may not be essential for accurate performance of a simple object-discrimination task.
本实验研究了大鼠嗅周皮质（PeRh）损伤对其物体辨别逆行记忆及逆行物体识别的影响。大鼠在手术前4周学习一个辨别问题或五个同时进行的辨别问题，并在手术前一周学习一个新问题或五个新问题。每只大鼠还在手术前5周、3周或1周时，在开阔场地熟悉一个样本物体。嗅周皮质损伤的大鼠在物体辨别问题上表现出正常的记忆保持，但在新奇偏好测试中，它们表现出对样本物体识别受损的迹象。在物体辨别学习和顺行物体识别测试中也观察到了类似的分离现象。研究结果表明，嗅周皮质在大鼠辨别手术前后曾遇到过的物体熟悉度的能力中起着至关重要的作用，但这种能力对于简单物体辨别任务的准确执行可能并非必不可少。
