Laudański T, Rocki W
Acta Physiol Pol. 1975 Jul-Aug;26(4):385-93.
The effects of stretching and of prostaglandin F2alpha on spontaneous and induced with local deformation contractile activity of rat uterus were studied. It was found that stretching the uterus up to the length of the decontracted organ in vivo increased the contractile and bioelectric activity. The rise in spontaneous uterine activity was a factor reducing induction of additional contractions. The fall in the level of endogenous prostaglandins in the uterus following administration of indomethacin inhibited the spontaneous contractile activity but was without effect on the contractions induced by local deformation of the myometrium. Prostaglandin F2alpha added to the bath in a concentration of 0.001 ng/ml exerted an inhibitory action on the different tested parameters of the contractile activity. After high doses stimulation of the uterine activity was observed.
研究了拉伸和前列腺素F2α对大鼠子宫自发收缩活动以及局部变形诱导的收缩活动的影响。发现在体内将子宫拉伸至去收缩状态器官的长度会增加收缩和生物电活动。子宫自发活动的增强是减少额外收缩诱导的一个因素。给予吲哚美辛后子宫内源性前列腺素水平下降，抑制了自发收缩活动，但对子宫肌层局部变形诱导的收缩没有影响。以0.001 ng/ml的浓度添加到浴液中的前列腺素F2α对收缩活动的不同测试参数产生抑制作用。高剂量后观察到子宫活动受到刺激。
