Marom Edith M, Sarvis Sarah, Herndon James E, Patz Edward F
Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA.
Radiology. 2002 May;223(2):453-9. doi: 10.1148/radiol.2232011131.
To determine the sensitivity of fluorodeoxyglucose (FDG) positron emission tomography (PET) in patients with T1 (< or =3 cm) lung cancers.
One hundred eighty-five patients with 192 histopathologically proved T1 lung cancers underwent FDG PET imaging at the time of diagnosis. PET results were correlated with tumor size, histopathologic findings, and patient outcome by using the two-sample t test, exact chi(2) test, and log rank test, respectively.
Of the 192 lesions, 183 (95%) that ranged in size from 0.5 to 3.0 cm in diameter (mean, 2.0 cm) were positive at PET (ie, demonstrated increased FDG uptake). Of the 192 lesions, nine (5%) that ranged in size from 0.3 to 2.5 cm in diameter (mean, 1.3 cm) were negative at PET (ie, demonstrated low FDG uptake). Patients with small tumors, as well as those with carcinoid tumors and bronchioloalveolar cell carcinoma, were more likely to have a negative PET scan (P =.004, P =.003, respectively). In addition, patients with a negative PET scan who subsequently proved to have cancer had significantly longer survival than did patients with a positive scan and cancer (P =.043).
Most T1 lung cancers show increased FDG uptake on PET scans.
确定氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）在T1期（≤3 cm）肺癌患者中的敏感性。
185例经组织病理学证实为T1期肺癌的患者在诊断时接受了FDG PET成像。分别使用两样本t检验、确切卡方检验和对数秩检验，将PET结果与肿瘤大小、组织病理学结果及患者预后进行相关性分析。
192个病灶中，直径0.5至3.0 cm（平均2.0 cm）的183个（95%）在PET检查时呈阳性（即显示FDG摄取增加）。192个病灶中，直径0.3至2.5 cm（平均1.3 cm）的9个（5%）在PET检查时呈阴性（即显示FDG摄取较低）。肿瘤较小的患者以及患有类癌和细支气管肺泡癌的患者PET扫描更有可能呈阴性（分别为P = 0.004，P = 0.003）。此外，PET扫描呈阴性且随后被证实患有癌症的患者的生存期明显长于PET扫描呈阳性且患有癌症的患者（P = 0.043）。
大多数T1期肺癌在PET扫描中显示FDG摄取增加。
