双氯芬酸钠在环糊精水溶液及水 - 乙醇混合溶液中的量热研究

Calorimetric studies of diclofenac sodium in aqueous solution of cyclodextrin and water-ethanol mixtures.

作者信息

Chadha R, Kashid N, Kumar A, Jain D V S

机构信息

Pharmaceutical Chemistry Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.

出版信息

J Pharm Pharmacol. 2002 Apr;54(4):481-6. doi: 10.1211/0022357021778745.

DOI:10.1211/0022357021778745

PMID:11999124

Abstract

The technique of solution calorimetry has been employed to study the interaction between diclofenac sodium and beta-cyclodextrin by determining the enthalpies of solution of the drug in water and in aqueous beta-cyclodextrin solution. Thermodynamic parameters characterizing the binding process such as enthalpy deltaH0, equilibrium constant K, free energy deltaG0 and entropy deltaS0 have been calculated to be 12.00 kJ mol(-1), 1670 dm3 mol(-1), -19.03kJ mol(-1) and 22.98 J K(-1) mol(-1), respectively. Enthalpies of solution of diclofenac sodium have also been determined in water-ethanol mixtures.

摘要

采用溶液量热法，通过测定双氯芬酸钠在水和β-环糊精水溶液中的溶解焓，研究了双氯芬酸钠与β-环糊精之间的相互作用。表征结合过程的热力学参数，如焓变ΔH0、平衡常数K、自由能变ΔG0和熵变ΔS0，经计算分别为12.00 kJ·mol⁻¹、1670 dm³·mol⁻¹、-19.03 kJ·mol⁻¹和22.98 J·K⁻¹·mol⁻¹。还测定了双氯芬酸钠在水 - 乙醇混合物中的溶解焓。